PlantImRecepV1, Main, Exploration, bibRecord, 000112

Molecular Mechanisms at the Basis of Pharmaceutical Grade Triticum vulgare Extract Efficacy in Prompting Keratinocytes Healing.

Identifieur interne : 000112 ( Main/Exploration ); précédent : 000111; suivant : 000113

Molecular Mechanisms at the Basis of Pharmaceutical Grade Triticum vulgare Extract Efficacy in Prompting Keratinocytes Healing.

Auteurs : Antonella D'Agostino [Italie] ; Anna Virginia Adriana Pirozzi [Italie] ; Rosario Finamore [Italie] ; Fabrizia Grieco [Italie] ; Massimiliano Minale [Italie] ; Chiara Schiraldi [Italie]

Source :

Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2020.

RBID : pubmed:31972968

Descripteurs français

KwdFr :
- Aquaporine-3 (métabolisme), Cicatrisation de plaie (effets des médicaments et des substances chimiques), Cicatrisation de plaie (génétique), Collagène de type I (métabolisme), Extraits de plantes (pharmacologie), Humains (MeSH), Imagerie accélérée (MeSH), Intégrine alphaV (métabolisme), Kératinocytes (anatomopathologie), Kératinocytes (effets des médicaments et des substances chimiques), Marqueurs biologiques (métabolisme), Masse moléculaire (MeSH), Régulation de l'expression des gènes (effets des médicaments et des substances chimiques), Survie cellulaire (effets des médicaments et des substances chimiques), Transcription génétique (effets des médicaments et des substances chimiques), Triticum (composition chimique), Viscosité (MeSH), Élastine (métabolisme).
MESH :
- anatomopathologie : Kératinocytes.
- composition chimique : Triticum.
- effets des médicaments et des substances chimiques : Cicatrisation de plaie, Kératinocytes, Régulation de l'expression des gènes, Survie cellulaire, Transcription génétique.
- génétique : Cicatrisation de plaie.
- métabolisme : Aquaporine-3, Collagène de type I, Intégrine alphaV, Marqueurs biologiques, Élastine.
- pharmacologie : Extraits de plantes.
- Humains, Imagerie accélérée, Masse moléculaire, Viscosité.

English descriptors

KwdEn :
- Aquaporin 3 (metabolism), Biomarkers (metabolism), Cell Survival (drug effects), Collagen Type I (metabolism), Elastin (metabolism), Gene Expression Regulation (drug effects), Humans (MeSH), Integrin alphaV (metabolism), Keratinocytes (drug effects), Keratinocytes (pathology), Molecular Weight (MeSH), Plant Extracts (pharmacology), Time-Lapse Imaging (MeSH), Transcription, Genetic (drug effects), Triticum (chemistry), Viscosity (MeSH), Wound Healing (drug effects), Wound Healing (genetics).
MESH :
- chemical , metabolism : Aquaporin 3, Biomarkers, Collagen Type I, Elastin, Integrin alphaV.
- chemistry : Triticum.
- drug effects : Cell Survival, Gene Expression Regulation, Keratinocytes, Transcription, Genetic, Wound Healing.
- genetics : Wound Healing.
- pathology : Keratinocytes.
- chemical , pharmacology : Plant Extracts.
- Humans, Molecular Weight, Time-Lapse Imaging, Viscosity.

Abstract

BACKGROUND

It has been shown that many plant- or microbial-derived oligos and polysaccharides may prompt tissue repair. Among the different extracts that have been studied, the aqueous one of Triticum vulgare (TVE) that was obtained from a whole germinated plant has been proven to have different biological properties that are useful in the process of wound healing. Nevertheless, with the long tradition of its use in pharmaceutical cream and ointments, especially in Italy, a new protocol was recently proposed (and patented) to improve the extraction process.

METHODS

In a simplified in vitro model, human keratinocyte monolayers were scratched and used to run time lapse experiments by using time lapse video microscopy (TLVM) to quantify reparation rate while considering a dose-response effect. Contemporarily, the molecular mechanisms that are involved in tissue repair were studied. In fact, key biomarkers that are involved in remodeling, such as MMP-2 and MMP-9, and in matrix structure assembly, such as collagen I, elastin, integrin αV and aquaporin 3, were evaluated with gene expression analyses (RT-PCR) and protein quantification in western blotting.

RESULTS

All TVE doses tested on the HaCat-supported cell proliferation. TVE also prompted cell migration in respect to the control, correctly modulating the timing of metalloproteases expression toward a consistent and well-assessed matrix remodeling. Furthermore, TVE treatments upregulated and positively modulated the expression of the analyzed biomarkers, thus resulting in a better remodeling of dermal tissue during healing.

CONCLUSIONS

The in vitro results on the beneficial effects of TVE on tissue elasticity and regeneration may support a better understanding of the action mechanism of TVE as active principles in pharmaceutical preparation in wound treatment.

DOI: 10.3390/molecules25030431
PubMed: 31972968
PubMed Central: PMC7037555

Affiliations:

Italie

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000239
to stream Main, to step Curation: 000239

Le document en format XML

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 Extract Efficacy in Prompting Keratinocytes Healing.</title>
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<term>Biomarkers (metabolism)</term>
<term>Cell Survival (drug effects)</term>
<term>Collagen Type I (metabolism)</term>
<term>Elastin (metabolism)</term>
<term>Gene Expression Regulation (drug effects)</term>
<term>Humans (MeSH)</term>
<term>Integrin alphaV (metabolism)</term>
<term>Keratinocytes (drug effects)</term>
<term>Keratinocytes (pathology)</term>
<term>Molecular Weight (MeSH)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Time-Lapse Imaging (MeSH)</term>
<term>Transcription, Genetic (drug effects)</term>
<term>Triticum (chemistry)</term>
<term>Viscosity (MeSH)</term>
<term>Wound Healing (drug effects)</term>
<term>Wound Healing (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Aquaporine-3 (métabolisme)</term>
<term>Cicatrisation de plaie (effets des médicaments et des substances chimiques)</term>
<term>Cicatrisation de plaie (génétique)</term>
<term>Collagène de type I (métabolisme)</term>
<term>Extraits de plantes (pharmacologie)</term>
<term>Humains (MeSH)</term>
<term>Imagerie accélérée (MeSH)</term>
<term>Intégrine alphaV (métabolisme)</term>
<term>Kératinocytes (anatomopathologie)</term>
<term>Kératinocytes (effets des médicaments et des substances chimiques)</term>
<term>Marqueurs biologiques (métabolisme)</term>
<term>Masse moléculaire (MeSH)</term>
<term>Régulation de l'expression des gènes (effets des médicaments et des substances chimiques)</term>
<term>Survie cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Transcription génétique (effets des médicaments et des substances chimiques)</term>
<term>Triticum (composition chimique)</term>
<term>Viscosité (MeSH)</term>
<term>Élastine (métabolisme)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aquaporin 3</term>
<term>Biomarkers</term>
<term>Collagen Type I</term>
<term>Elastin</term>
<term>Integrin alphaV</term>
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<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Triticum</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term>
<term>Gene Expression Regulation</term>
<term>Keratinocytes</term>
<term>Transcription, Genetic</term>
<term>Wound Healing</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cicatrisation de plaie</term>
<term>Kératinocytes</term>
<term>Régulation de l'expression des gènes</term>
<term>Survie cellulaire</term>
<term>Transcription génétique</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Wound Healing</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cicatrisation de plaie</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Aquaporine-3</term>
<term>Collagène de type I</term>
<term>Intégrine alphaV</term>
<term>Marqueurs biologiques</term>
<term>Élastine</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Keratinocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Extraits de plantes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Molecular Weight</term>
<term>Time-Lapse Imaging</term>
<term>Viscosity</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Imagerie accélérée</term>
<term>Masse moléculaire</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>It has been shown that many plant- or microbial-derived oligos and polysaccharides may prompt tissue repair. Among the different extracts that have been studied, the aqueous one of Triticum vulgare (TVE) that was obtained from a whole germinated plant has been proven to have different biological properties that are useful in the process of wound healing. Nevertheless, with the long tradition of its use in pharmaceutical cream and ointments, especially in Italy, a new protocol was recently proposed (and patented) to improve the extraction process.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>In a simplified in vitro model, human keratinocyte monolayers were scratched and used to run time lapse experiments by using time lapse video microscopy (TLVM) to quantify reparation rate while considering a dose-response effect. Contemporarily, the molecular mechanisms that are involved in tissue repair were studied. In fact, key biomarkers that are involved in remodeling, such as MMP-2 and MMP-9, and in matrix structure assembly, such as collagen I, elastin, integrin αV and aquaporin 3, were evaluated with gene expression analyses (RT-PCR) and protein quantification in western blotting.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>All TVE doses tested on the HaCat-supported cell proliferation. TVE also prompted cell migration in respect to the control, correctly modulating the timing of metalloproteases expression toward a consistent and well-assessed matrix remodeling. Furthermore, TVE treatments upregulated and positively modulated the expression of the analyzed biomarkers, thus resulting in a better remodeling of dermal tissue during healing.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>The in vitro results on the beneficial effects of TVE on tissue elasticity and regeneration may support a better understanding of the action mechanism of TVE as active principles in pharmaceutical preparation in wound treatment.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>11</Month>
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<DateRevised><Year>2020</Year>
<Month>11</Month>
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<Month>Jan</Month>
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<Title>Molecules (Basel, Switzerland)</Title>
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<ArticleTitle>Molecular Mechanisms at the Basis of Pharmaceutical Grade <i>Triticum vulgare</i>
 Extract Efficacy in Prompting Keratinocytes Healing.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">It has been shown that many plant- or microbial-derived oligos and polysaccharides may prompt tissue repair. Among the different extracts that have been studied, the aqueous one of Triticum vulgare (TVE) that was obtained from a whole germinated plant has been proven to have different biological properties that are useful in the process of wound healing. Nevertheless, with the long tradition of its use in pharmaceutical cream and ointments, especially in Italy, a new protocol was recently proposed (and patented) to improve the extraction process.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">In a simplified in vitro model, human keratinocyte monolayers were scratched and used to run time lapse experiments by using time lapse video microscopy (TLVM) to quantify reparation rate while considering a dose-response effect. Contemporarily, the molecular mechanisms that are involved in tissue repair were studied. In fact, key biomarkers that are involved in remodeling, such as MMP-2 and MMP-9, and in matrix structure assembly, such as collagen I, elastin, integrin αV and aquaporin 3, were evaluated with gene expression analyses (RT-PCR) and protein quantification in western blotting.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">All TVE doses tested on the HaCat-supported cell proliferation. TVE also prompted cell migration in respect to the control, correctly modulating the timing of metalloproteases expression toward a consistent and well-assessed matrix remodeling. Furthermore, TVE treatments upregulated and positively modulated the expression of the analyzed biomarkers, thus resulting in a better remodeling of dermal tissue during healing.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The in vitro results on the beneficial effects of TVE on tissue elasticity and regeneration may support a better understanding of the action mechanism of TVE as active principles in pharmaceutical preparation in wound treatment.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>D'Agostino</LastName>
<ForeName>Antonella</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pirozzi</LastName>
<ForeName>Anna Virginia Adriana</ForeName>
<Initials>AVA</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Finamore</LastName>
<ForeName>Rosario</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Grieco</LastName>
<ForeName>Fabrizia</ForeName>
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<AffiliationInfo><Affiliation>Farmaceutici Damor, Naples 80145, Italy.</Affiliation>
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<Author ValidYN="Y"><LastName>Minale</LastName>
<ForeName>Massimiliano</ForeName>
<Initials>M</Initials>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schiraldi</LastName>
<ForeName>Chiara</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>CDS 000463</GrantID>
<Agency>INVITALIA-Italy</Agency>
<Country></Country>
</Grant>
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<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>01</Month>
<Day>21</Day>
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<ISSNLinking>1420-3049</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D024042">Collagen Type I</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D039564">Integrin alphaV</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance>
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<Chemical><RegistryNumber>158801-98-0</RegistryNumber>
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<Chemical><RegistryNumber>9007-58-3</RegistryNumber>
<NameOfSubstance UI="D004549">Elastin</NameOfSubstance>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D051400" MajorTopicYN="N">Aquaporin 3</DescriptorName>
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<CoiStatement>M.M. and F.G. are enrolled in Damor Farmaceutici, they were involved in the preparation of the extract and in the preparation of the introduction section and partially on the discussion of results however they were not involved in the experimental set-up of biological assays that were run at the Department of Experimental Medicine. All the authors from the University of Campania “Luigi Vanvitelli” declare no conflict of interest.</CoiStatement>
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<ReferenceList><Reference><Citation>Dermatol Res Pract. 2011;2011:978291</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21747844</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Des Devel Ther. 2015 May 27;9:2787-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26060395</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Mol Sci. 2019 Sep 24;20(19):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31554177</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nutrients. 2019 Jun 14;11(6):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31207929</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Ethnopharmacol. 2019 Jun 28;238:111844</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30940568</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Drug Investig. 2012 Jan 1;32(1):41-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22035444</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Biol Macromol. 2018 Dec;120(Pt B):1682-1695</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30287361</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Environ Res Public Health. 2018 Oct 25;15(11):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30366427</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Cell Biol. 2015 Jul 11;16:19</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26163378</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Appl Biochem Biotechnol. 2019 Jun;188(2):381-394</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30474796</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Wound Repair Regen. 2019 Jul;27(4):415-420</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30873727</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2018 Jun 14;13(6):e0197493</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29902182</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>G Batteriol Virol Immunol. 1978 Jul-Dec;71(7-12):176-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">549567</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antioxidants (Basel). 2018 May 17;7(5):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29772758</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Anal Chim Acta. 2017 Mar 15;958:59-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28110685</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Carbohydr Polym. 2017 Feb 10;157:128-136</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27987833</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Photodiagnosis Photodyn Ther. 2017 Dec;20:71-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28807774</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Biochem Biophys. 2011 Apr 15;508(2):138-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21276418</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2016 Oct 10;11(10):e0163510</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27723763</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Med Rep. 2018 Sep;18(3):3461-3468</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30066901</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Ethnopharmacol. 2015 Jan 15;159:198-208</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25446580</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Essays Biochem. 2019 Oct 31;63(5):535-551</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31444228</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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Molecular Mechanisms at the Basis of Pharmaceutical Grade Triticum vulgare Extract Efficacy in Prompting Keratinocytes Healing.

Molecular Mechanisms at the Basis of Pharmaceutical Grade Triticum vulgare Extract Efficacy in Prompting Keratinocytes Healing.

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